Torsemide

Oral bioavailability: 80-90%

Onset of action: diuresis 30-60m, peak 1-4h

Metabolism: hepatic

Half-life: 2-4h, cirrhosis 7-8h

Excretion: urine, 20% unchanged

Price: $0.63 (5mg) - $2.53 (100mg) per day / furosemide $0.46 per day

In an open-label trial compared with furosemide, there was a significant decrease in readmissions for heart failure and CV causes, ARR 15% for both, NNT 6.7, p = <0.01 / 0.03 respectively. There was a non-significant reduction in death from all causes. (re: Murray MD. AMJ 2001; 111; 513)